How Nutrition, Sleep, and Metabolic Health Impact PRP Results | Conversations in Regen Episode 16

Seeing uneven PRP results even when your injections are technically sound? [Learn what to do before PRP injection to consistently improve outcomes.]
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In this episode, Dr. Ariana DeMers, the Queen of Business Orthobiologic, is joined by Dr. Ashu Goyle—double board-certified in anesthesiology and pain management—for a deep clinical conversation on why patient optimization is the missing variable in many PRP cases. Together, they unpack how nutrition, sleep, metabolic health, and lifestyle factors directly influence platelet function, growth factor release, and tissue repair in orthobiologics and regenerative medicine.

Rather than focusing on technique alone, this discussion explores what to do before a PRP injection to create a biologic environment that supports healing. Topics include inflammatory load, insulin resistance, protein intake, vitamin deficiencies, sleep architecture, stress physiology, and why “prehab” is essential for predictable PRP outcomes. Dr. Goyle shares real-world protocols from his regenerative practice, while Dr. Ariana connects these principles to reproducible clinical results and long-term patient trust.

This episode is essential viewing for physicians who want better PRP results, fewer failed cases, and a more systems-based approach to regenerative care that treats the patient—not just the pathology.

Chapters
06:40 How does nutrition affect platelet function?
12:42 How do you pre-op optimize patients prior to injections?
17:23 Does fasting improve PRP outcomes?
21:20 How does better sleep support regenerative healing?
25:55 What Is the most effective short-term pre-PRP preparation?
33:51 What considerations to take for PRP in patients with kidney disease?
35:20 What nutrition program do you use for your patients?
39:46 Is it advisable to administer PRP and ozone therapy or hyperbaric treatment?
44:10 Insights on vagus nerve stimulators, and PRP as a preventative measure
47:08 Dr. Ashu Goyle journey to a building a thriving independent practice

If this conversation reshaped how you think about PRP and regenerative outcomes, like, comment, and subscribe for more expert discussions with leaders in orthobiologics. Ready to apply these principles in your own practice? Visit my Website : https://pxllnk.co/AD/BOBsite

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